Endocrine Abstracts

Objective: The human androgen recteptor (AR) contains a polyglutamine and a polyglycine stretch that are highly polymorphic and are coded by a CAG and GGN repeat, respectively, in exon 1 of the AR gene. Although in vitro studies indicated a possible effect on AR gene tanscription and clinical observations suggest a modulation of androgen action, the functional significance of the GGN repeat remains unclear.We wanted to assess whether the GGN repea...